Job Req ID:  562

Vancouver, BC, CAN

Additional Locations:  N/A

Research Associate II, Protein Engineering

Company Description
Zymeworks is a publicly listed (NASDAQ: ZYME) clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation, biospecific and multifunctional biotherapeutics, initially focused on the treatment of cancer. Zymeworks' suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates. 


Why Work With Us

Nothing is more critical to our success than the quality of our team.   The work we do is meaningful and impactful - we care about each other as well as the patients we serve.  We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.  


Zymeworks is seeking a motivated professional looking to grow their career with our company. The Protein Engineering team produces, purifies, and characterizes novel protein therapeutics from discovery through to lead candidate selection and develops, optimizes and validates new methods, technologies and processes for delivering high-quality data to accelerate the advancement of pipeline programs and platform technologies. The Research Associate will provide hands-on support for protein engineering efforts from discovery through to candidate selection of novel therapeutics.


The ideal candidate will have a background in protein biochemistry and/or structural biology, be able to interact across functional groups, and capable of working in a dynamic and fast-paced environment.


Zymeworks is proudly headquartered in our brand new, net-zero facility located in the vibrant Main St biotech hub of Vancouver, BC, with operations in Seattle, WA, San Francisco, CA and Dublin, Ireland.  We offer a hybrid work environment with most team members working in-office three days per week. 


Job Description

  • Performs purification workflows to support research programs and projects
  • Provides analytical and biophysical characterization of antibodies and other protein therapeutics, including designing, planning and executing experiments, either independently or in collaboration with teammates
  • Analyzes and reviews data, draws conclusions and makes recommendations for future investigations.
  • Troubleshoots methods and suggests novel and impactful changes.
  • Writes procedures for methods requiring significant technical understanding, data manipulation and calculations. Identifies opportunities to improve existing methods and develop new technologies for project advancement.
  • Participates in study design and plans experiments to advance program.
  • Prepares written reports and analysis of complex experiments.
  • Participates in cross-departmental activities and presents data.
  • Seeks to understand ongoing projects through attention to scientific literature, industry publications and internally generated data and employs this understanding to improve contribution to project goals.
  • Maintains a clean, organized and operational lab. 
  • Conducts all activities in accordance with scientific standards, OH&S regulations and established policies and practices.
  • Actively works to foster an environment of effective and collaborative working relationships across the organization.


  • A BSc in scientific discipline and a minimum of 2-5 years related experience or an equivalent combination of education and experience.
  • Good working knowledge and hands-on experience in any of the following areas:
  • Protein analytics: PAGE, CE-SDS, HPLC-SEC, cIEF, HIC, Western Blotting, ELISA, MSD, DSC, DSF, DLS, MALS.
  • Binding kinetics by one of the following methods: SPR, BLI, Kinexa.
  • Protein purification (e.g. protein A/G/L, IEX, IMAC, and SEC) and familiarity with AKTA (FPLC) system.
  • Proven interpersonal skills with the ability to work collaboratively as a member of cross-functional team.
  • Demonstrated scientific analysis and problem-solving skills.
  • Good organizational skills and the ability to work effectively in a high paced, fast changing environment. Results-oriented.
  • Good critical observation skills and good statistical analysis capability.
  • Good oral presentation and scientific/technical writing skills.
  • Ability to present data at team and inter-departmental meetings.


Total Rewards

We offer a comprehensive total rewards package, which includes competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth.  We regularly benchmark our compensation against leading biotechnology companies in our geographies.  


Our team enjoys: 

  • Industry leading vacation and paid time off
  • Excellent health and wellness benefits
  • Zymelife health and wellness benefits
  • Paid time off to volunteer in your community
  • Matching RRSP / 401K program
  • Employee Share Purchase Program
  • Employee Equity Program


All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin or disability. 


NOTE TO AGENCIES:  Zymeworks values our relationships with our recruiting partners.  We only accept resumes from those partners who have been contracted with us.  Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.  

Date:  Jan 19, 2023