Job Req ID:  1136

San Francisco, CA, USA

Additional Locations:  Vancouver, Bellevue
Department:  Clinical Pharmacology
Job Type:  Full Time
Workplace Type:  Hybrid

Scientist, Pharmacometrics


Company Description
Zymeworks is a publicly listed (NASDAQ:ZYME) clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation, bispecific and multifunctional biotherapeutics, initially focused on the treatment of cancer.   Zymeworks' suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates.  


Why Work With Us

Nothing is more critical to our success than the quality of our team.   The work we do is meaningful and impactful - we care about each other as well as the patients we serve.  We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.  


Zymeworks is proudly headquartered in our brand new, net-zero facility located in the vibrant Main St biotech hub of Vancouver, BC, with operations in Bellevue, WA, Dublin, Ireland, Singapore and the Bay Area.


Work Requirement

This role will be based out of our Redwood City, CA office and is hybrid with a minimum of 3 days per week onsite. 

About the Role

This position will be part of the Clinical Pharmacology and Translational Sciences team, and will be responsible to support the Pharmacometrics and Clinical Pharmacology Leads in the development and execution of Quantitative Systems Pharmacology (QSP) and mechanistic Pharmacokinetics/Pharmacodynamic (PK/PD) Modeling and Simulation activities related to the research, design, implementation, data analysis, interpretation, reporting, and publication of Clinical Pharmacology and Pharmacometris supported studies for products in the early phase of development. This position will work in close partnership with colleagues in Clinical Pharmacology, Biostatistics, Nonclinical Development, Bioanalysis, and Biometrics, as well as with external vendors and partners creating an aligned, quantitative framework to impact strategies and decisions on drug development. The successful candidate will have good quantitative pharmacology skills, scientific reasoning, written and verbal communication skills, exploratory graphical analysis skills, study design and report writing skills.


This individual will utilize a variety of analytic software including MATLAB to design, build, and apply QSP modeling approaches to support decision making within the team. Models may describe a drug's mechanism of action, pharmacokinetics, disease mechanisms, and drug toxicities. The successful candidate will be familiar with quantitative approaches in drug development and have hands-on experience with relevant software (e.g. MATLAB, SAS, R).

Key Responsibilities

  • Assist in developing and implementing QSP modeling strategies to predict drug behavior in biological systems, incorporating mechanistic understanding of pharmacokinetics and pharmacodynamics. 
  • Support PK/PD data analysis and interpretation, providing programming expertise to support data preparation and visualization. 
  • Collaborate with research scientists to integrate preclinical and clinical data into QSP and PK/PD frameworks. 
  • Collaborate with Clinical Pharmacologists and Biostatisticians to integrate modeling results into clinical trial design, dose selection, and drug development pathways.

Education and Experience

  • PhD in Pharmacokinetics, Pharmaceutical Sciences, Biomedical Engineering or related discipline.  An equivalent combination of education and applicable experience may be considered.
  • A minimum of 2 years of relevant modeling experience is required.



Skills and Abilities:

  • Hands-on experience in Quantitative Clinical Pharmacology approaches with a focus on QSP and PK/PD modeling.
  • Experience with general modeling and simulation software (e.g. MATLAB, SimBiology, Julia, Python, NONMEM, Monolix, etc.) would be particularly desirable. 
  • Good understanding of the basic principles of pharmacokinetics and pharmacodynamics for conventional large and small molecule therapeutics modalities.
  • Excellent interpersonal and collaborative skills, with a professional demeanor and the ability to interact with all levels of management, colleagues and external collaborators.
  • Well organized with the ability to multitask, prioritize and manage shifting responsibilities in a small, fast-moving and entrepreneurial environment.
  • Ability to manage multiple, complex tasks with competing timelines.
  • Self-motivated and can independently manage responsibilities.
  • Ability to travel (<10%).


Total Rewards

We offer a comprehensive total rewards package, which includes competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth.  We regularly benchmark our compensation against leading biotechnology companies in our geographies.  

The US base salary range for this full-time position is $97,000 - $149,000 + bonus + equity + benefits. Our salary ranges are determined by role, level, and location. 

The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across all US locations. Within the range, individual pay is determined by a variety of factors and the salary offered may vary depending on the successful candidate’s location and qualifications (including, but not limited to, job-related knowledge, education, training, skills, and experience).


Please note that the compensation details listed in US role postings reflect the base salary only, and do not include bonus, equity, or benefits. This role is also eligible for a competitive benefits package that includes: 

  • Industry leading vacation and paid time off
  • Excellent health and wellness benefits
  • Zymelife health and wellness benefits
  • Paid time off to volunteer in your community
  • Matching RRSP / 401K program
  • Employee Share Purchase Program
  • Employee Equity Program


All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin or disability. 


NOTE TO AGENCIES:  Zymeworks values our relationships with our recruiting partners.  We only accept resumes from those partners who have been contracted with us.  Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.  

Date:  Jul 19, 2024

Nearest Major Market: San Francisco
Nearest Secondary Market: Oakland