Job Req ID:  582

Vancouver, BC, CAN

Additional Locations:  CA
Department:  Protein Antibody

Research Associate II, Protein Engineering (Library Design & Purification)

Company Description
Zymeworks is a publicly listed (NASDAQ: ZYME) clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation, biospecific and multifunctional biotherapeutics, initially focused on the treatment of cancer. Zymeworks' suite of complementary therapeutic platforms and its fully-integrated drug development engine provide the flexibility and compatibility to precisely engineer and develop highly-differentiated product candidates. 


Why Work With Us

Nothing is more critical to our success than the quality of our team.   The work we do is meaningful and impactful - we care about each other as well as the patients we serve.  We offer challenging career opportunities, competitive benefits and an environment that recognizes and rewards performance.  


Zymeworks is seeking a motivated professional looking to grow their career with our company. The Protein Engineering team design, purifies, and characterizes novel protein therapeutics from early discovery to lead candidate selection. We develop new methods, technologies and processes to accelerate the advancement of multispecific pipeline programs and platform technologies. The Research Associate will provide hands-on support in early discovery phase and novel therapeutics optimization through design, production and screening of multispecific libraries. This position will report to our Scientist in Protein Engineering and will be based in our labs in Vancouver BC.​


Zymeworks is proudly headquartered in our brand new, net-zero facility located in the vibrant Main St biotech hub of Vancouver, BC, with operations in Seattle, WA, San Francisco, CA and Dublin, Ireland.  We offer a hybrid work environment with most team members working in-office three days per week. 



Job Description

  • Design, plan and execute molecular biology workflows to design libraries of multispecific antibodies compatible with mammalian display technologies.
  • Participate in protein purification and analytical characterization of lead molecules.
  • Troubleshoot methods, suggest improvements and develop new technologies for project advancement.
  • Write standard operating procedures for methods requiring significant technical understanding, data manipulation and calculations.
  • Analyze data, draw conclusions and participate in cross-departmental activities.
  • Maintain a clean, organized and operational lab. 
  • Conduct all activities in accordance with scientific standards, OH&S regulations and established policies and practices.
  • Actively work to foster an environment of effective and collaborative working relationships across the organization.


  • A BSc in a relevant scientific discipline (biochemistry, immunology, etc.) and a minimum of 2-3 years related experience or a Master’s degree with an equivalent combination of education and experience


Skills and Abilities

  • Experience in molecular biology (e.g. PCR, cloning via restriction enzyme, Golden Gate or Gibson Assembly) and library preparation.
  • Experience with some of the following techniques:
  • Protein purification (affinity, protein A/G/L, IEX, and SEC).
  • Protein characterization, (e.g. PAGE, CE-SDS, ELISA, SPR, BLI, KinExA, MSD, UPLC-SEC)
  • Automation
  • Ability to work collaboratively as a member of cross-functional team.
  • Good organizational skills and the ability to work effectively in a high paced, fast changing environment. Result-oriented.
  • Ability to present data at team and inter-departmental meetings.


Total Rewards

We offer a comprehensive total rewards package, which includes competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth.  We regularly benchmark our compensation against leading biotechnology companies in our geographies.  


Our team enjoys: 

  • Industry leading vacation and paid time off
  • Excellent health and wellness benefits
  • Zymelife health and wellness benefits
  • Paid time off to volunteer in your community
  • Matching RRSP / 401K program
  • Employee Share Purchase Program
  • Employee Equity Program


All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin or disability. 


NOTE TO AGENCIES:  Zymeworks values our relationships with our recruiting partners.  We only accept resumes from those partners who have been contracted with us.  Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.  

Date:  Jan 19, 2023